While traditional medicine puts an emphasis on affected organs or systems, digital solutions are exploiting commonalities between seemingly unrelated medical conditions. These commonalities are redrawing the disease landscape, and are impacting medical care and disease management. We establish a disease-connection framework by identifying six key facets of digital health – monitoring, diagnostics, predictive analytics, therapeutics, assistive technology, and behavior augmentation. We overlay disease connections on top of a technology maturity and crowding analysis to form a framework that could be applied to any set of diseases. With this framework, we identify potential applications for existing solutions, technological challenges, and upcoming shifts in business models. Based on the analysis, we outline possible changes in supply chains and technology development, and we re-imagine the future hospital.